Neal McDonough was born on February 13, 1966 in Dorchester, Massachusetts, to Catherine (Bushe) and Frank McDonough, motel owners who were born in Ireland. He grew up in Barnstable, Massachusetts, graduated from Barnstable High School, and attended Syracuse University. He was a member of the Sigma Chi Fraternity and graduated with a Bachelor's degree in Fine Arts in 1988. McDonough frequently appeared as Captain Laser, inspiring young students to bring their studies to completion. Fron there, he trained for a short time at the London Academy of Music and Dramatic Art. McDonough has made many television and film appearances since 1991, including Star Trek: First Contact (1996), Minority Report (2002), Timeline (2003), Walking Tall (2004), The Guardian (2006) and Flags of Our Fathers (2006). His most recent television appearances include Band of Brothers (2001), Boomtown (2002) Desperate Housewives (2004), Medical Investigation (2004), Tin Man (2007) and Justified (2010).
Neal's most prized accomplishment is his wife Ruve, whom he married in 2003. They live in Los Angeles, California with their four children.